28 Oktober 2022 |
| 18h00 | BK-46 Karis (FIN) | 37 - 20 |  Spor Toto SK (TUR) |
| 18h30 | Nærbø IL (NOR) | 29 - 28 |  RK Slovenj Gradec 2011 (SLO) |
| 19h30 | HC Fivers WAT Margareten Wenen (AUT) | 29 - 30 |  KA Akureyri (ISL) |
29 Oktober 2022 |
| 16h00 | Polva Serviti (EST) | 27 - 26 |  Viljandi HC (EST) |
| 16h00 | VHC Sviesa Vilnius (LTU) | 28 - 31 |  Red Boys Differdange (LUX) |
| 16h00 | IL Runar Sandefjord (NOR) | Geannuleerd |  RK Lovcen Cetinje (MNE) |
| 16h00 | OIF Arendal Elite (NOR) | 34 - 20 |  HC Robe Zubri (CZE) |
| 18h00 | RK Gorenje Velenje (SLO) | 32 - 30 |  Bregenz Handball (AUT) |
| 18h00 | Dinamo Pancevo (SRB) | 32 - 22 |  PM Conversano (ITA) |
| 18h00 | RK Gracanica (BIH) | 33 - 17 |  HC Baki (AZE) |
| 18h00 | MSK Povazska Bystrica (SVK) | 33 - 25 |  RK Izvidac Ljubuski (BIH) |
| 18h15 | KA Akureyri (ISL) | 26 - 30 | HC Fivers WAT Margareten Wenen (AUT) |
| 18h15 | HB Esch-sur-Alzette (LUX) | 31 - 36 |  HC Dukla Praha (CZE) |
| 19h00 | SSV Brixen Handball (ITA) | 23 - 31 |  Vojvodina Novi Sad (SRB) |
| 19h00 | HRK Gorica (CRO) | 27 - 25 |  TJ Sokol Nové Veselí (CZE) |
| 19h00 | HV KRAS/Volendam (NED) | 27 - 31 |  Wacker Thun (SUI) |
| 19h00 | UHK Krems (AUT) | 34 - 25 |  A.E.S.C.H. Pylaias (GRE) |
| 19h00 | RD Ribnica RH (SLO) | 40 - 19 |  RK Borac Banja Luka (BIH) |
| 20h00 | HC Visé BM (BEL) | 38 - 21 |  Parnassos Strovolou (CYP) |
| 20h00 | OCI Limburg Lions Geleen (NED) | 39 - 17 |  Lokomotiv Gorna (BUL) |
30 Oktober 2022 |
| 12h00 | Spor Toto SK (TUR) | 23 - 43 | BK-46 Karis (FIN) |
| 16h00 | IFK Handball Helsinki (FIN) | 28 - 27 |  BESA Famgas Peja (KOS) |
| 17h00 | Parnassos Strovolou (CYP) | 19 - 24 | HC Visé BM (BEL) |
| 17h00 | Viljandi HC (EST) | 28 - 33 | Polva Serviti (EST) |
| 17h00 | Red Boys Differdange (LUX) | 34 - 22 | VHC Sviesa Vilnius (LTU) |
| 17h00 | AEK Athens (GRE) | 35 - 30 |  JMS Hurry-Up Zwartemeer (NED) |
| 18h00 | Pfadi Winterthur (SUI) | 34 - 30 |  AS Ramat HaSharon (ISR) |
| 19h00 | HC Baki (AZE) | 28 - 37 | RK Gracanica (BIH) |
| 19h00 | KH Rahoveci (KOS) | 29 - 33 |  HC Banik Karvina (CZE) |
| 19h00 | A.E.S.C.H. Pylaias (GRE) | 30 - 34 | UHK Krems (AUT) |
| 19h30 | Olympiacos SFP Piraeus (GRE) | 34 - 24 |  RK Sloboda Tuzla (BIH) |
| 20h00 | Beykoz BLD SK Istanbul (TUR) | 28 - 32 |  Alingsas HK (SWE) |
| 20h00 | MRK Sesvete (CRO) | 29 - 24 |  AC PAOK Thessaloniki (GRE) |
31 Oktober 2022 |
| 19h00 | Alingsas HK (SWE) | 46 - 21 | Beykoz BLD SK Istanbul (TUR) |
4 November 2022 |
| 18h00 | H71 Hoyvik (FAR) | 21 - 27 |  RK Partizan Belgrado (SRB) |
5 November 2022 |
| 14h00 | HC Granitas-Karys Kaunas (LTU) | 21 - 31 |  Besiktas JK Istanbul (TUR) |
| 15h00 | HC Donbass Donetsk (UKR) | 28 - 36 |  IB Vestmannaeyja (ISL) |
| 16h00 | TJ Sokol Nové Veselí (CZE) | 26 - 28 | HRK Gorica (CRO) |
| 17h00 | Wacker Thun (SUI) | 23 - 25 | HV KRAS/Volendam (NED) |
| 17h00 | AS Ramat HaSharon (ISR) | 31 - 24 | Pfadi Winterthur (SUI) |
| 17h30 | RK Lovcen Cetinje (MNE) | 31 - 31 | IL Runar Sandefjord (NOR) |
| 18h00 | Lokomotiv Gorna (BUL) | 19 - 39 | OCI Limburg Lions Geleen (NED) |
| 18h00 | HC Robe Zubri (CZE) | 26 - 36 | OIF Arendal Elite (NOR) |
| 18h00 | HC Dukla Praha (CZE) | 30 - 32 | HB Esch-sur-Alzette (LUX) |
| 18h00 | TENAX Dobele (LAT) | 31 - 28 |  SSK Talent Plzen (CZE) |
| 18h00 | Vojvodina Novi Sad (SRB) | 44 - 27 | SSV Brixen Handball (ITA) |
| 18h30 | PM Conversano (ITA) | 30 - 27 | Dinamo Pancevo (SRB) |
| 19h00 | JMS Hurry-Up Zwartemeer (NED) | 17 - 25 | AEK Athens (GRE) |
| 19h00 | Bregenz Handball (AUT) | 25 - 26 | RK Gorenje Velenje (SLO) |
| 19h00 | Anorthosis Famagusta HB (CYP) | 26 - 22 |  Haukar Hafnarfjordur (ISL) |
| 19h00 | RK Slovenj Gradec 2011 (SLO) | 27 - 29 | Nærbø IL (NOR) |
| 19h00 | Junior Fasano (ITA) | 32 - 33 |  Hapoel Ashdod (ISR) |
| 19h00 | RK Izvidac Ljubuski (BIH) | 36 - 32 | MSK Povazska Bystrica (SVK) |
| 20h00 | RK Sloboda Tuzla (BIH) | 19 - 27 | Olympiacos SFP Piraeus (GRE) |
| 20h00 | HC Banik Karvina (CZE) | 32 - 29 | KH Rahoveci (KOS) |
6 November 2022 |
| 14h00 | Besiktas JK Istanbul (TUR) | 27 - 25 | HC Granitas-Karys Kaunas (LTU) |
| 15h00 | AC PAOK Thessaloniki (GRE) | 21 - 27 | MRK Sesvete (CRO) |
| 15h00 | IB Vestmannaeyja (ISL) | 45 - 20 | HC Donbass Donetsk (UKR) |
| 18h00 | SSK Talent Plzen (CZE) | 29 - 25 | TENAX Dobele (LAT) |
| 18h00 | RK Borac Banja Luka (BIH) | 30 - 28 | RD Ribnica RH (SLO) |
| 18h00 | RK Partizan Belgrado (SRB) | 35 - 30 | H71 Hoyvik (FAR) |
| 18h00 | BESA Famgas Peja (KOS) | 35 - 32 | IFK Handball Helsinki (FIN) |
| 19h00 | Hapoel Ashdod (ISR) | 26 - 32 | Junior Fasano (ITA) |
| 19h00 | Haukar Hafnarfjordur (ISL) | 28 - 36 | Anorthosis Famagusta HB (CYP) |
TuSEM Essen
Adrian Petrea Resita
Valur Reykjavik